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Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies

Tau is a microtubule-associated protein that accumulates in at least 15 different neurodegenerative disorders, which are collectively referred to as tauopathies. In these diseases, tau is often hyperphosphorylated and found in aggregates, including paired helical filaments, neurofibrillary tangles a...

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Bibliografski detalji
Glavni autori: Miyata, Yoshinari, Koren, John, Kiray, Janine, Dickey, Chad A, Gestwicki, Jason E
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190966/
https://ncbi.nlm.nih.gov/pubmed/21882945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.11.88
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