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Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies
Tau is a microtubule-associated protein that accumulates in at least 15 different neurodegenerative disorders, which are collectively referred to as tauopathies. In these diseases, tau is often hyperphosphorylated and found in aggregates, including paired helical filaments, neurofibrillary tangles a...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3190966/ https://ncbi.nlm.nih.gov/pubmed/21882945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.11.88 |
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