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A chemical compound inhibiting the Aha1–Hsp90 chaperone complex

The eukaryotic Hsp90 chaperone machinery comprises many co-chaperones and regulates the conformation of hundreds of cytosolic client proteins. Therefore, it is not surprising that the Hsp90 machinery has become an attractive therapeutic target for diseases such as cancer. The compounds used so far t...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Stiegler, Sandrine C., Rübbelke, Martin, Korotkov, Vadim S., Weiwad, Matthias, John, Christine, Fischer, Gunter, Sieber, Stephan A., Sattler, Michael, Buchner, Johannes
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641884/
https://ncbi.nlm.nih.gov/pubmed/28851842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797829
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