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A chemical compound inhibiting the Aha1–Hsp90 chaperone complex

The eukaryotic Hsp90 chaperone machinery comprises many co-chaperones and regulates the conformation of hundreds of cytosolic client proteins. Therefore, it is not surprising that the Hsp90 machinery has become an attractive therapeutic target for diseases such as cancer. The compounds used so far t...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Stiegler, Sandrine C., Rübbelke, Martin, Korotkov, Vadim S., Weiwad, Matthias, John, Christine, Fischer, Gunter, Sieber, Stephan A., Sattler, Michael, Buchner, Johannes
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641884/
https://ncbi.nlm.nih.gov/pubmed/28851842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797829
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