Loading...

A chemical compound inhibiting the Aha1–Hsp90 chaperone complex

The eukaryotic Hsp90 chaperone machinery comprises many co-chaperones and regulates the conformation of hundreds of cytosolic client proteins. Therefore, it is not surprising that the Hsp90 machinery has become an attractive therapeutic target for diseases such as cancer. The compounds used so far t...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Stiegler, Sandrine C., Rübbelke, Martin, Korotkov, Vadim S., Weiwad, Matthias, John, Christine, Fischer, Gunter, Sieber, Stephan A., Sattler, Michael, Buchner, Johannes
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641884/
https://ncbi.nlm.nih.gov/pubmed/28851842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797829
Tags: Add Tag
No Tags, Be the first to tag this record!