Importance of cycle timing for the function of the molecular chaperone Hsp90

Hsp90 couples ATP hydrolysis to large conformational changes essential for activation of client proteins. The structural transitions involve dimerization of the N-terminal domains and formation of ‘closed states’ involving the N-terminal and middle domains. Here, we used Hsp90 mutants that modulate...

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Publicado en:Nat Struct Mol Biol
Main Authors: Zierer, Bettina K, Rübbelke, Martin, Tippel, Franziska, Madl, Tobias, Schopf, Florian H, Rutz, Daniel A, Richter, Klaus, Sattler, Michael, Buchner, Johannes
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248305/
https://ncbi.nlm.nih.gov/pubmed/27723736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3305
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