Hop/Sti1 phosphorylation inhibits its co-chaperone function

In eukaryotes, the molecular chaperones Hsp90 and Hsp70 are connected via the co-chaperone Sti1/Hop, which allows transfer of clients. Here, we show that the basic functions of yeast Sti1 and human Hop are conserved. These include the simultaneous binding of Hsp90 and Hsp70, the inhibition of the AT...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Rep
Prif Awduron: Röhl, Alina, Tippel, Franziska, Bender, Evelyn, Schmid, Andreas B, Richter, Klaus, Madl, Tobias, Buchner, Johannes
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BlackWell Publishing Ltd 2015
Pynciau:
Scientific Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4328751/
https://ncbi.nlm.nih.gov/pubmed/25504578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439198
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