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Dynamics of the regulation of Hsp90 by the co-chaperone Sti1

In eukaryotic cells, Hsp90 chaperones assist late folding steps of many regulatory protein clients by a complex ATPase cycle. Binding of clients to Hsp90 requires prior interaction with Hsp70 and a transfer reaction that is mediated by the co-chaperone Sti1/Hop. Sti1 furthers client transfer by inhi...

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Hlavní autoři: Lee, Chung-Tien, Graf, Christian, Mayer, Franz J, Richter, Sebastian M, Mayer, Matthias P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321184/
https://ncbi.nlm.nih.gov/pubmed/22354036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.37
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