Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

The cochaperone Sti1/Hop physically links Hsp70 and Hsp90. The protein exhibits one binding site for Hsp90 (TPR2A) and two binding sites for Hsp70 (TPR1 and TPR2B). How these sites are used remained enigmatic. Here we show that Sti1 is a dynamic, elongated protein that consists of a flexible N-termi...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Röhl, Alina, Wengler, Daniela, Madl, Tobias, Lagleder, Stephan, Tippel, Franziska, Herrmann, Monika, Hendrix, Jelle, Richter, Klaus, Hack, Gordon, Schmid, Andreas B., Kessler, Horst, Lamb, Don C., Buchner, Johannes
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Pub. Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403447/
https://ncbi.nlm.nih.gov/pubmed/25851214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7655
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