Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

The cochaperone Sti1/Hop physically links Hsp70 and Hsp90. The protein exhibits one binding site for Hsp90 (TPR2A) and two binding sites for Hsp70 (TPR1 and TPR2B). How these sites are used remained enigmatic. Here we show that Sti1 is a dynamic, elongated protein that consists of a flexible N-termi...

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Pubblicato in:Nat Commun
Autori principali: Röhl, Alina, Wengler, Daniela, Madl, Tobias, Lagleder, Stephan, Tippel, Franziska, Herrmann, Monika, Hendrix, Jelle, Richter, Klaus, Hack, Gordon, Schmid, Andreas B., Kessler, Horst, Lamb, Don C., Buchner, Johannes
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403447/
https://ncbi.nlm.nih.gov/pubmed/25851214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7655
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