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A methylated lysine is a switch point for conformational communication in the chaperone Hsp90
Methylation of a conserved lysine in C-terminal domain of the molecular chaperone Hsp90 was shown previously to affect its in vivo function. However, the underlying mechanism remained elusive. Through a combined experimental and computational approach, this study shows that this site is very sensiti...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7057950/ https://ncbi.nlm.nih.gov/pubmed/32139682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15048-8 |
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