A methylated lysine is a switch point for conformational communication in the chaperone Hsp90

Methylation of a conserved lysine in C-terminal domain of the molecular chaperone Hsp90 was shown previously to affect its in vivo function. However, the underlying mechanism remained elusive. Through a combined experimental and computational approach, this study shows that this site is very sensiti...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Rehn, Alexandra, Lawatscheck, Jannis, Jokisch, Marie-Lena, Mader, Sophie L., Luo, Qi, Tippel, Franziska, Blank, Birgit, Richter, Klaus, Lang, Kathrin, Kaila, Ville R. I., Buchner, Johannes
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057950/
https://ncbi.nlm.nih.gov/pubmed/32139682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15048-8
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