Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90

Hsp90 is a molecular chaperone involved in the activation of numerous client proteins, including many kinases. The most stringent kinase client is the oncogenic kinase v-Src. To elucidate how Hsp90 chaperones kinases, we reconstituted v-Src kinase chaperoning in vitro and show that its activation is...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Boczek, Edgar E., Reefschläger, Lasse G., Dehling, Marco, Struller, Tobias J., Häusler, Elisabeth, Seidl, Andreas, Kaila, Ville R. I., Buchner, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485149/
https://ncbi.nlm.nih.gov/pubmed/26056257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424342112
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados