Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90

Hsp90 is a molecular chaperone involved in the activation of numerous client proteins, including many kinases. The most stringent kinase client is the oncogenic kinase v-Src. To elucidate how Hsp90 chaperones kinases, we reconstituted v-Src kinase chaperoning in vitro and show that its activation is...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Boczek, Edgar E., Reefschläger, Lasse G., Dehling, Marco, Struller, Tobias J., Häusler, Elisabeth, Seidl, Andreas, Kaila, Ville R. I., Buchner, Johannes
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485149/
https://ncbi.nlm.nih.gov/pubmed/26056257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424342112
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