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Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90

The heat shock protein 90 (Hsp90) is a molecular chaperone that employs the free energy of ATP hydrolysis to control the folding and activation of several client proteins in the eukaryotic cell. To elucidate how the local ATPase reaction in the active site couples to the global conformational dynami...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Mader, Sophie L., Lopez, Abraham, Lawatscheck, Jannis, Luo, Qi, Rutz, Daniel A., Gamiz-Hernandez, Ana P., Sattler, Michael, Buchner, Johannes, Kaila, Ville R. I.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075974/
https://ncbi.nlm.nih.gov/pubmed/32179743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15050-0
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