Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90

The heat shock protein 90 (Hsp90) is a molecular chaperone that employs the free energy of ATP hydrolysis to control the folding and activation of several client proteins in the eukaryotic cell. To elucidate how the local ATPase reaction in the active site couples to the global conformational dynami...

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Udgivet i:Nat Commun
Main Authors: Mader, Sophie L., Lopez, Abraham, Lawatscheck, Jannis, Luo, Qi, Rutz, Daniel A., Gamiz-Hernandez, Ana P., Sattler, Michael, Buchner, Johannes, Kaila, Ville R. I.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075974/
https://ncbi.nlm.nih.gov/pubmed/32179743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15050-0
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