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Dynamic Aha1 co‐chaperone binding to human Hsp90

Hsp90 is an essential chaperone that requires large allosteric changes to determine its ATPase activity and client binding. The co‐chaperone Aha1, which is the major ATPase stimulator in eukaryotes, is important for regulation of Hsp90's allosteric timing. Little is known, however, about the st...

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Foilsithe in:Protein Sci
Main Authors: Oroz, Javier, Blair, Laura J., Zweckstetter, Markus
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley & Sons, Inc. 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699087/
https://ncbi.nlm.nih.gov/pubmed/31299134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3678
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