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Dynamic Aha1 co‐chaperone binding to human Hsp90

Hsp90 is an essential chaperone that requires large allosteric changes to determine its ATPase activity and client binding. The co‐chaperone Aha1, which is the major ATPase stimulator in eukaryotes, is important for regulation of Hsp90's allosteric timing. Little is known, however, about the st...

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Vydáno v:Protein Sci
Hlavní autoři: Oroz, Javier, Blair, Laura J., Zweckstetter, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699087/
https://ncbi.nlm.nih.gov/pubmed/31299134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3678
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