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Cooperative Nucleotide Binding in Hsp90 and Its Regulation by Aha1

The function of the molecular chaperone Hsp90 depends on large conformational changes, the rearrangement of local motifs, and the binding and hydrolysis of ATP. The size and complexity of the Hsp90 system impedes the detailed investigation of their interplay using standard methods. To overcome this...

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Vydáno v:Biophys J
Hlavní autoři: Wortmann, Philipp, Götz, Markus, Hugel, Thorsten
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647574/
https://ncbi.nlm.nih.gov/pubmed/29045865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.032
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