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Cooperative Nucleotide Binding in Hsp90 and Its Regulation by Aha1

The function of the molecular chaperone Hsp90 depends on large conformational changes, the rearrangement of local motifs, and the binding and hydrolysis of ATP. The size and complexity of the Hsp90 system impedes the detailed investigation of their interplay using standard methods. To overcome this...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Wortmann, Philipp, Götz, Markus, Hugel, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647574/
https://ncbi.nlm.nih.gov/pubmed/29045865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.032
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