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Effects of inhibitors on Hsp90's conformational dynamics, cochaperone and client interactions

The molecular chaperone and heat-shock protein Hsp90 has become a central target in anti-cancer therapy. Nevertheless, the effect of Hsp90 inhibition is still not understood at the molecular level, preventing a truly rational drug design. Here we report on the effect of the most prominent drug candi...

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Détails bibliographiques
Publié dans:Chemphyschem
Auteurs principaux: Schmid, Sonja, Götz, Markus, Hugel, Thorsten
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525096/
https://ncbi.nlm.nih.gov/pubmed/29677383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cphc.201800342
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