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Effects of inhibitors on Hsp90's conformational dynamics, cochaperone and client interactions
The molecular chaperone and heat-shock protein Hsp90 has become a central target in anti-cancer therapy. Nevertheless, the effect of Hsp90 inhibition is still not understood at the molecular level, preventing a truly rational drug design. Here we report on the effect of the most prominent drug candi...
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| Publié dans: | Chemphyschem |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6525096/ https://ncbi.nlm.nih.gov/pubmed/29677383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cphc.201800342 |
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