Llwytho...

Effects of inhibitors on Hsp90's conformational dynamics, cochaperone and client interactions

The molecular chaperone and heat-shock protein Hsp90 has become a central target in anti-cancer therapy. Nevertheless, the effect of Hsp90 inhibition is still not understood at the molecular level, preventing a truly rational drug design. Here we report on the effect of the most prominent drug candi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chemphyschem
Prif Awduron: Schmid, Sonja, Götz, Markus, Hugel, Thorsten
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525096/
https://ncbi.nlm.nih.gov/pubmed/29677383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cphc.201800342
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