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Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid

Niemann-Pick type C (NPC) disease is primarily caused by mutations in the NPC1 gene and is characterized by the accumulation of unesterified cholesterol and lipids in the late endosomal (LE) and lysosomal (Ly) compartments. The most prevalent disease-linked mutation is the I1061T variant of NPC1, wh...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Subramanian, Kanagaraj, Hutt, Darren M., Scott, Samantha M., Gupta, Vijay, Mao, Shu, Balch, William E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278344/
https://ncbi.nlm.nih.gov/pubmed/32354745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010524
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