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The Potential of Histone Deacetylase Inhibitors in Niemann–Pick Type C Disease
Niemann-Pick type C (NPC) disease is a fatal complex neurodegenerative lysosomal storage disorder caused by genetic mutations in either NPC1 (95% of patients) or NPC2 that decrease intracellular cholesterol trafficking resulting in accumulation of unesterified cholesterol and sphingolipids in lysoso...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857996/ https://ncbi.nlm.nih.gov/pubmed/23992240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12505 |
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