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Treatment of Niemann–Pick Type C Disease by Histone Deacetylase Inhibitors

Niemann–Pick type C disease (NPC) is a devastating, recessive, inherited disorder that causes accumulation of cholesterol and other lipids in late endosomes and lysosomes. Mutations in 2 genes, NPC1 and NPC2, are responsible for the disease, which affects about 1 in 120,000 live births. About 95 % o...

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Bibliografske podrobnosti
Main Authors: Helquist, Paul, Maxfield, Frederick R., Wiech, Norbert L., Wiest, Olaf
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805865/
https://ncbi.nlm.nih.gov/pubmed/24048860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-013-0217-2
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