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Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann-Pick Type C Disease Therapeutics

Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized at the cellular level by abnormal accumulation of cholesterol and other lipids in lysosomal storage organelles. Lysosomal acid lipase (LAL) has been recently identified as a potential therapeutic target for NPC. LAL can...

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Bibliografiske detaljer
Main Authors: Rosenbaum, Anton I., Cosner, Casey C., Mariani, Christopher J., Maxfield, Frederick R., Wiest, Olaf, Helquist, Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912405/
https://ncbi.nlm.nih.gov/pubmed/20557099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100499s
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