CHEMICAL SCREEN TO REDUCE STEROL ACCUMULATION IN NIEMANN-PICK C DISEASE CELLS IDENTIFIES NOVEL LYSOSOMAL ACID LIPASE INHIBITORS

Niemann-Pick C disease (NPC) is a lysosomal storage disorder causing abnormal accumulation of unesterified free cholesterol in lysosomal storage organelles. High content phenotypic microscopy chemical screens in both human and hamster NPC-deficient cells have identified several compounds that partia...

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Detalhes bibliográficos
Main Authors: Rosenbaum, Anton I., Rujoi, Madalina, Huang, Amy Y., Du, Hong, Grabowski, Gregory A., Maxfield, Frederick R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783675/
https://ncbi.nlm.nih.gov/pubmed/19699313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2009.08.005
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