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CHEMICAL SCREEN TO REDUCE STEROL ACCUMULATION IN NIEMANN-PICK C DISEASE CELLS IDENTIFIES NOVEL LYSOSOMAL ACID LIPASE INHIBITORS
Niemann-Pick C disease (NPC) is a lysosomal storage disorder causing abnormal accumulation of unesterified free cholesterol in lysosomal storage organelles. High content phenotypic microscopy chemical screens in both human and hamster NPC-deficient cells have identified several compounds that partia...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2009
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2783675/ https://ncbi.nlm.nih.gov/pubmed/19699313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2009.08.005 |
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