Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics

A five-step synthesis of an array of N-aryl-3-alkylidenepyrrolinones, which are potential Niemann-Pick type C (NPC) disease therapeutics, is described. The synthetic route allows for the production of analogues, including photoaffinity and biotinylated derivatives. Compound 1a increased esterificati...

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Detaylı Bibliyografya
Asıl Yazarlar: Cosner, Casey C., Markiewicz, John T., Bourbon, Pauline, Mariani, Christopher J., Wiest, Olaf, Rujoi, Madalina, Rosenbaum, Anton, Huang, Amy, Maxfield, Frederick R., Helquist, Paul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791921/
https://ncbi.nlm.nih.gov/pubmed/19772346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900707n
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