Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics

A five-step synthesis of an array of N-aryl-3-alkylidenepyrrolinones, which are potential Niemann-Pick type C (NPC) disease therapeutics, is described. The synthetic route allows for the production of analogues, including photoaffinity and biotinylated derivatives. Compound 1a increased esterificati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cosner, Casey C., Markiewicz, John T., Bourbon, Pauline, Mariani, Christopher J., Wiest, Olaf, Rujoi, Madalina, Rosenbaum, Anton, Huang, Amy, Maxfield, Frederick R., Helquist, Paul
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791921/
https://ncbi.nlm.nih.gov/pubmed/19772346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900707n
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