Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann-Pick Type C Disease Therapeutics

Por Rosenbaum, Anton I., Cosner, Casey C., Mariani, Christopher J., Maxfield, Frederick R., Wiest, Olaf, Helquist, Paul
Publicado em 2010

Selective Oxidation of Benzylic and Allylic Alcohols Using Mn(OAc)(3)/Catalytic 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

Por Cosner, Casey C., Cabrera Ventura, Pablo J., Byrd, Katherine M., Adams Thomas, Asia M., Helquist, Paul
Publicado no Org Lett (2011)

Improved Synthesis of MDL 73811 – a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound

Por Brockway, Anthony J., Cosner, Casey C., Volkov, Oleg A., Phillips, Margaret A., De Brabander, Jef K.
Publicado no Synthesis (Stuttg) (2016)

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

Por Pipalia, Nina H., Cosner, Casey C., Huang, Amy, Chatterjee, Anamitra, Bourbon, Pauline, Farley, Nathan, Helquist, Paul, Wiest, Olaf, Maxfield, Frederick R.
Publicado em 2011

Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics

Por Cosner, Casey C., Markiewicz, John T., Bourbon, Pauline, Mariani, Christopher J., Wiest, Olaf, Rujoi, Madalina, Rosenbaum, Anton, Huang, Amy, Maxfield, Frederick R., Helquist, Paul
Publicado em 2009

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) – an inhibitor of S-adenosylmethionine decarboxylase with an...

Por Brockway, Anthony J., Volkov, Oleg A., Cosner, Casey C., MacMillan, Karen S., Wring, Stephen A., Richardson, Thomas E., Peel, Michael, Phillips, Margaret A., De Brabander, Jef K.
Publicado no Bioorg Med Chem (2017)

Identification of Trypanosoma brucei AdoMetDC inhibitors using a high-throughput mass spectrometry-based assay

Por Volkov, Oleg A., Cosner, Casey C., Brockway, Anthony J., Kramer, Martin, Booker, Michael, Zhong, Shihua, Ketcherside, Ariel, Wei, Shuguang, Longgood, Jamie, McCoy, Melissa, Richardson, Thomas E., Wring, Stephen A., Peel, Michael, Klinger, Jeffrey D., Posner, Bruce A., De Brabander, Jef K., Phillips, Margaret A.
Publicado no ACS Infect Dis (2017)

Substituted Hippurates and Hippurate Analogs as Substrates and Inhibitors of Peptidylglycine α-Hydroxylating Monooxygenase (PHM)

Por Merkler, David J., Asser, Alexander S., Baumgart, Laura E., Carballo, Natalie, Carpenter, Sarah E., Chew, Geoffrey H., Cosner, Casey C., Dusi, Jodi, Galloway, Lamar C., Lowe, Andrew B., Lowe, Edward W., King, Lawrence, Kendig, Robert D., Kline, Paul C., Malka, Robert, Merkler, Kathleen A., McIntyre, Neil R., Romero, Mindy, Wilcox, Benjamin J., Owen, Terence C.
Publicado em 2008