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Improved Synthesis of MDL 73811 – a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound

An improved synthesis of MDL 73811 – a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound with in vivo activity has been completed in four steps from commercially available 2′,3′-O-isopropylideneadenosine. Utilization of Mitsunobu chemistry was crucial for...

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Bibliografiske detaljer
Udgivet i:Synthesis (Stuttg)
Main Authors: Brockway, Anthony J., Cosner, Casey C., Volkov, Oleg A., Phillips, Margaret A., De Brabander, Jef K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966539/
https://ncbi.nlm.nih.gov/pubmed/27482123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0035-1561608
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