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Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways

S-adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. We report the design, synthesis, and evaluation of stable, functional AdoMet isosteres that are resistant to the primary contributors to Ad...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:ACS Chem Biol
Päätekijät: Huber, Tyler D., Wang, Fengbin, Singh, Shanteri, Johnson, Brooke R., Zhang, Jianjun, Sunkara, Manjula, Van Lanen, Steven G., Morris, Andrew J., Phillips, George N., Thorson, Jon S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026608/
https://ncbi.nlm.nih.gov/pubmed/27351335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00348
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