Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways

S-adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. We report the design, synthesis, and evaluation of stable, functional AdoMet isosteres that are resistant to the primary contributors to Ad...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Huber, Tyler D., Wang, Fengbin, Singh, Shanteri, Johnson, Brooke R., Zhang, Jianjun, Sunkara, Manjula, Van Lanen, Steven G., Morris, Andrew J., Phillips, George N., Thorson, Jon S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026608/
https://ncbi.nlm.nih.gov/pubmed/27351335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00348
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