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Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes

The structural conservation among methyltransferases (MTs) and MT functional redundancy is a major challenge to the cellular study of individual MTs. As a first step toward the development of an alternative biorthogonal platform for MTs and other AdoMet-utilizing enzymes, we describe the evaluation...

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Publicat a:ACS Chem Biol
Autors principals: Huber, Tyler D., Clinger, Jonathan A., Liu, Yang, Xu, Weijun, Miller, Mitchell D., Phillips, George N., Thorson, Jon S.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516136/
https://ncbi.nlm.nih.gov/pubmed/32091873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00943
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