Identification of Trypanosoma brucei AdoMetDC inhibitors using a high-throughput mass spectrometry-based assay

Human African trypanosomiasis (HAT) is a fatal infectious disease caused by the eukaryotic pathogen Trypanosoma brucei. Available treatments are difficult to administer and have significant safety issues. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the parasite polyamine...

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發表在:ACS Infect Dis
Main Authors: Volkov, Oleg A., Cosner, Casey C., Brockway, Anthony J., Kramer, Martin, Booker, Michael, Zhong, Shihua, Ketcherside, Ariel, Wei, Shuguang, Longgood, Jamie, McCoy, Melissa, Richardson, Thomas E., Wring, Stephen A., Peel, Michael, Klinger, Jeffrey D., Posner, Bruce A., De Brabander, Jef K., Phillips, Margaret A.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511061/
https://ncbi.nlm.nih.gov/pubmed/28350440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00022
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