Identification of Trypanosoma brucei AdoMetDC inhibitors using a high-throughput mass spectrometry-based assay

Human African trypanosomiasis (HAT) is a fatal infectious disease caused by the eukaryotic pathogen Trypanosoma brucei. Available treatments are difficult to administer and have significant safety issues. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the parasite polyamine...

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Publié dans:ACS Infect Dis
Auteurs principaux: Volkov, Oleg A., Cosner, Casey C., Brockway, Anthony J., Kramer, Martin, Booker, Michael, Zhong, Shihua, Ketcherside, Ariel, Wei, Shuguang, Longgood, Jamie, McCoy, Melissa, Richardson, Thomas E., Wring, Stephen A., Peel, Michael, Klinger, Jeffrey D., Posner, Bruce A., De Brabander, Jef K., Phillips, Margaret A.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511061/
https://ncbi.nlm.nih.gov/pubmed/28350440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00022
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