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Improved Synthesis of MDL 73811 – a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound
An improved synthesis of MDL 73811 – a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound with in vivo activity has been completed in four steps from commercially available 2′,3′-O-isopropylideneadenosine. Utilization of Mitsunobu chemistry was crucial for...
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| Publicado no: | Synthesis (Stuttg) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966539/ https://ncbi.nlm.nih.gov/pubmed/27482123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0035-1561608 |
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