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Substituted Hippurates and Hippurate Analogs as Substrates and Inhibitors of Peptidylglycine α-Hydroxylating Monooxygenase (PHM)

Peptidyl α-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of α-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and as insecticides for the management of insect pest...

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Detalhes bibliográficos
Main Authors: Merkler, David J., Asser, Alexander S., Baumgart, Laura E., Carballo, Natalie, Carpenter, Sarah E., Chew, Geoffrey H., Cosner, Casey C., Dusi, Jodi, Galloway, Lamar C., Lowe, Andrew B., Lowe, Edward W., King, Lawrence, Kendig, Robert D., Kline, Paul C., Malka, Robert, Merkler, Kathleen A., McIntyre, Neil R., Romero, Mindy, Wilcox, Benjamin J., Owen, Terence C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668526/
https://ncbi.nlm.nih.gov/pubmed/18952446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.10.013
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