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Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs

Peptidylglycine α-amidating monooxygenase (PAM) is a bifunctional enzyme that catalyzes the final reaction in the maturation of α-amidated peptide hormones. Peptidylglycine α-hydroxylating monooxygenase (PHM) is the PAM domain responsible for the copper-, ascorbate- and O(2)-dependent hydroxylation...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Autores principales: McIntyre, Neil R., Lowe, Edward W., Battistini, Matthew R., Leahy, James W., Merkler, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801743/
https://ncbi.nlm.nih.gov/pubmed/26024288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/14756366.2015.1046064
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