Substituted Hippurates and Hippurate Analogs as Substrates and Inhibitors of Peptidylglycine α-Hydroxylating Monooxygenase (PHM)

Peptidyl α-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of α-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and as insecticides for the management of insect pest...

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Auteurs principaux: Merkler, David J., Asser, Alexander S., Baumgart, Laura E., Carballo, Natalie, Carpenter, Sarah E., Chew, Geoffrey H., Cosner, Casey C., Dusi, Jodi, Galloway, Lamar C., Lowe, Andrew B., Lowe, Edward W., King, Lawrence, Kendig, Robert D., Kline, Paul C., Malka, Robert, Merkler, Kathleen A., McIntyre, Neil R., Romero, Mindy, Wilcox, Benjamin J., Owen, Terence C.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668526/
https://ncbi.nlm.nih.gov/pubmed/18952446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.10.013
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