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Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3–mediated translation initiation
Inherited and somatic rare diseases result from >200,000 genetic variants leading to loss- or gain-of-toxic function, often caused by protein misfolding. Many of these misfolded variants fail to properly interact with other proteins. Understanding the link between factors mediating the transcript...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6120211/ https://ncbi.nlm.nih.gov/pubmed/30006345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003192 |
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