Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides That Restore Trafficking and Activity of ΔF508-CFTR

[Image: see text] Cystic fibrosis (CF) is a loss-of-function disease caused by mutations in the CF transmembrane conductance regulator (CFTR) protein, a chloride ion channel that localizes to the apical plasma membrane of epithelial cells. The most common form of the disease results from the deletio...

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Main Authors: Hutt, Darren M., Olsen, Christian A., Vickers, Chris J., Herman, David, Chalfant, Monica A., Montero, Ana, Leman, Luke J., Burkle, Renner, Maryanoff, Bruce E., Balch, William E., Ghadiri, M. Reza
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2011
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187562/
https://ncbi.nlm.nih.gov/pubmed/21984958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200136e
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