The CFTR-Associated Ligand arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER contributing to Cystic Fibrosis

INTRODUCTION: The CFTR-Associated Ligand (CAL), a PDZ domain containing protein with two coiled-coil domains, reduces cell surface WT CFTR through degradation in the lysosome by a well-characterized mechanism. However, CAL’s regulatory effect on ΔF508 CFTR has remained almost entirely uninvestigated...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Physiol Biochem
Main Authors: Bergbower, E.A.S., Boinot, C., Sabirzhanova, I., Guggino, W.B., Cebotaru, L.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861351/
https://ncbi.nlm.nih.gov/pubmed/29402832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000487120
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares