Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction

The molecular pharmacology of the G protein–coupled receptors for sphingosine 1-phosphate (S1P) provides important insight into established and new therapeutic targets. A new, potent bitopic S1P(3) antagonist, SPM-354, with in vivo activity, has been used, together with S1P(3)-knockin and S1P(3)-kno...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Sanna, M. Germana, Vincent, Kevin P., Repetto, Emanuela, Nguyen, Nhan, Brown, Steven J., Abgaryan, Lusine, Riley, Sean W., Leaf, Nora B., Cahalan, Stuart M., Kiosses, William B., Kohno, Yasushi, Brown, Joan Heller, McCulloch, Andrew D., Rosen, Hugh, Gonzalez-Cabrera, Pedro J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702096/
https://ncbi.nlm.nih.gov/pubmed/26494861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.100222
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