Novel Selective Allosteric and Bitopic Ligands for the S1P(3) Receptor

Sphingosine 1-phosphate (S1P) is a lysophospholipid signaling molecule that regulates important biological functions, including lymphocyte trafficking and vascular development, by activating G protein-coupled receptors for S1P, namely S1P(1) through S1P(5). Here we map the S1P(3) binding pocket with...

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Main Authors: Jo, Euijung, Bhhatarai, Barun, Repetto, Emanuela, Guerrero, Miguel, Riley, Sean, Brown, Steven J., Kohno, Yasushi, Roberts, Edward, Schürer, Stephan C., Rosen, Hugh
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528827/
https://ncbi.nlm.nih.gov/pubmed/22971058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300392z
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