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Bitopic ligands: all-in-one orthosteric and allosteric

Natural ligands of G-protein-coupled receptors interact with the orthosteric ligand binding site, as do most of the classical synthetic ligands. The discovery of ligands targeting different, allosteric binding sites considerably expanded the repertoire of G-protein-coupled receptor ligands. More rec...

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Bibliographic Details
Main Authors: Kamal, Maud, Jockers, Ralf
Format: Artigo
Language:Inglês
Published: Biology Reports Ltd 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948289/
https://ncbi.nlm.nih.gov/pubmed/20948611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3410/B1-77
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