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Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand
[Image: see text] The RORγt nuclear receptor (NR) is of critical importance for the differentiation and proliferation of T helper 17 (Th17) cells and their production of the pro-inflammatory cytokine IL-17a. Dysregulation of RORγt has been linked to various autoimmune diseases, and small molecule in...
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| Publicado en: | ACS Chem Biol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical
Society
2021
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8023582/ https://ncbi.nlm.nih.gov/pubmed/33596047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00941 |
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