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Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

The demand for allosteric targeting of nuclear receptors is high, but examples are limited, and structural information is scarce. The retinoic acid‐related orphan receptor gamma t (RORγt) is an important transcriptional regulator for the differentiation of T helper 17 cells for which the first, and...

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Bibliografische gegevens
Gepubliceerd in:ChemMedChem
Hoofdauteurs: de Vries, Rens M. J. M., Doveston, Richard G., Meijer, Femke A., Brunsveld, Luc
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187189/
https://ncbi.nlm.nih.gov/pubmed/32053744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000044
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