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Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist
The demand for allosteric targeting of nuclear receptors is high, but examples are limited, and structural information is scarce. The retinoic acid‐related orphan receptor gamma t (RORγt) is an important transcriptional regulator for the differentiation of T helper 17 cells for which the first, and...
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| Gepubliceerd in: | ChemMedChem |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
John Wiley and Sons Inc.
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7187189/ https://ncbi.nlm.nih.gov/pubmed/32053744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000044 |
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