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Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt

Cooperative ligand binding is an important phenomenon in biological systems where ligand binding influences the binding of another ligand at an alternative site of the protein via an intramolecular network of interactions. The underlying mechanisms behind cooperative binding remain poorly understood...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: de Vries, Rens M. J. M., Meijer, Femke A., Doveston, Richard G., Leijten-van de Gevel, Iris A., Brunsveld, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017705/
https://ncbi.nlm.nih.gov/pubmed/33536342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021287118
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