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Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt

Cooperative ligand binding is an important phenomenon in biological systems where ligand binding influences the binding of another ligand at an alternative site of the protein via an intramolecular network of interactions. The underlying mechanisms behind cooperative binding remain poorly understood...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: de Vries, Rens M. J. M., Meijer, Femke A., Doveston, Richard G., Leijten-van de Gevel, Iris A., Brunsveld, Luc
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017705/
https://ncbi.nlm.nih.gov/pubmed/33536342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021287118
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