Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt

Cooperative ligand binding is an important phenomenon in biological systems where ligand binding influences the binding of another ligand at an alternative site of the protein via an intramolecular network of interactions. The underlying mechanisms behind cooperative binding remain poorly understood...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: de Vries, Rens M. J. M., Meijer, Femke A., Doveston, Richard G., Leijten-van de Gevel, Iris A., Brunsveld, Luc
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017705/
https://ncbi.nlm.nih.gov/pubmed/33536342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021287118
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