From RORγt Agonist to Two Types of RORγt Inverse Agonists

[Image: see text] Biaryl amides as new RORγt modulators were discovered. The crystal structure of biaryl amide agonist 6 in complex with RORγt ligand binding domain (LBD) was resolved, and both “short” and “long” inverse agonists were obtained by removing from 6 or adding to 6 a proper structural mo...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Wang, Yonghui, Cai, Wei, Tang, Ting, Liu, Qian, Yang, Ting, Yang, Liuqing, Ma, Yingli, Zhang, Guifeng, Huang, Yafei, Song, Xiaoxia, Orband-Miller, Lisa A., Wu, Qianqian, Zhou, Ling, Xiang, Zhijun, Xiang, Jia-Ning, Leung, Stewart, Shao, Liming, Lin, Xichen, Lobera, Mercedes, Ren, Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807863/
https://ncbi.nlm.nih.gov/pubmed/29456799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00476
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