Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders

od Xu, Heng, Lu, Hongfu, Xu, Zhongmiao, Luan, Linbo, Li, Chengyong, Xu, Yan, Dong, Kelly, Zhang, Jinqiang, Li, Xiong, Li, Yvonne, Liu, Gentao, Gong, Sophie, Zhao, Yong-Gang, Liu, Ailian, Zhang, Yueting, Zhang, Wei, Cai, Xin, Xiang, Jia-Ning, Elliott, John D., Lin, Xichen
izdano v ACS Med Chem Lett (2016)

From RORγt Agonist to Two Types of RORγt Inverse Agonists

od Wang, Yonghui, Cai, Wei, Tang, Ting, Liu, Qian, Yang, Ting, Yang, Liuqing, Ma, Yingli, Zhang, Guifeng, Huang, Yafei, Song, Xiaoxia, Orband-Miller, Lisa A., Wu, Qianqian, Zhou, Ling, Xiang, Zhijun, Xiang, Jia-Ning, Leung, Stewart, Shao, Liming, Lin, Xichen, Lobera, Mercedes, Ren, Feng
izdano v ACS Med Chem Lett (2018)

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists

od Yang, Ting, Liu, Qian, Cheng, Yaobang, Cai, Wei, Ma, Yingli, Yang, Liuqing, Wu, Qianqian, Orband-Miller, Lisa A., Zhou, Ling, Xiang, Zhijun, Huxdorf, Melanie, Zhang, Wei, Zhang, Jing, Xiang, Jia-Ning, Leung, Stewart, Qiu, Yang, Zhong, Zhong, Elliott, John D., Lin, Xichen, Wang, Yonghui
Izdano 2013

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

od Wang, Yonghui, Cai, Wei, Cheng, Yaobang, Yang, Ting, Liu, Qian, Zhang, Guifeng, Meng, Qinghua, Han, Fangbin, Huang, Yafei, Zhou, Ling, Xiang, Zhijun, Zhao, Yong-Gang, Xu, Yan, Cheng, Ziqiang, Lu, Sijie, Wu, Qianqian, Xiang, Jia-Ning, Elliott, John D., Leung, Stewart, Ren, Feng, Lin, Xichen
izdano v ACS Med Chem Lett (2015)

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

od Kerns, Jeffrey K., Busch-Petersen, Jakob, Fu, Wei, Boehm, Jeffrey C., Nie, Hong, Muratore, Michael, Bullion, Ann, Lin, Guoliang, Li, Huijie, Davis, Roderick, Lin, Xichen, Lakdawala, Ami S., Cousins, Rick, Field, Rita, Payne, Jeremy, Miller, David D., Bamborough, Paul, Christopher, John A., Baldwin, Ian, Osborn, Ruth R., Yonchuk, John, Webb, Edward, Rumsey, William L.
izdano v ACS Med Chem Lett (2018)

Small molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

od Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.
Izdano 2014