Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders

di Xu, Heng, Lu, Hongfu, Xu, Zhongmiao, Luan, Linbo, Li, Chengyong, Xu, Yan, Dong, Kelly, Zhang, Jinqiang, Li, Xiong, Li, Yvonne, Liu, Gentao, Gong, Sophie, Zhao, Yong-Gang, Liu, Ailian, Zhang, Yueting, Zhang, Wei, Cai, Xin, Xiang, Jia-Ning, Elliott, John D., Lin, Xichen
Pubblicato in ACS Med Chem Lett (2016)

From RORγt Agonist to Two Types of RORγt Inverse Agonists

di Wang, Yonghui, Cai, Wei, Tang, Ting, Liu, Qian, Yang, Ting, Yang, Liuqing, Ma, Yingli, Zhang, Guifeng, Huang, Yafei, Song, Xiaoxia, Orband-Miller, Lisa A., Wu, Qianqian, Zhou, Ling, Xiang, Zhijun, Xiang, Jia-Ning, Leung, Stewart, Shao, Liming, Lin, Xichen, Lobera, Mercedes, Ren, Feng
Pubblicato in ACS Med Chem Lett (2018)

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists

di Yang, Ting, Liu, Qian, Cheng, Yaobang, Cai, Wei, Ma, Yingli, Yang, Liuqing, Wu, Qianqian, Orband-Miller, Lisa A., Zhou, Ling, Xiang, Zhijun, Huxdorf, Melanie, Zhang, Wei, Zhang, Jing, Xiang, Jia-Ning, Leung, Stewart, Qiu, Yang, Zhong, Zhong, Elliott, John D., Lin, Xichen, Wang, Yonghui
Pubblicazione 2013

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

di Wang, Yonghui, Cai, Wei, Cheng, Yaobang, Yang, Ting, Liu, Qian, Zhang, Guifeng, Meng, Qinghua, Han, Fangbin, Huang, Yafei, Zhou, Ling, Xiang, Zhijun, Zhao, Yong-Gang, Xu, Yan, Cheng, Ziqiang, Lu, Sijie, Wu, Qianqian, Xiang, Jia-Ning, Elliott, John D., Leung, Stewart, Ren, Feng, Lin, Xichen
Pubblicato in ACS Med Chem Lett (2015)

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

di Kerns, Jeffrey K., Busch-Petersen, Jakob, Fu, Wei, Boehm, Jeffrey C., Nie, Hong, Muratore, Michael, Bullion, Ann, Lin, Guoliang, Li, Huijie, Davis, Roderick, Lin, Xichen, Lakdawala, Ami S., Cousins, Rick, Field, Rita, Payne, Jeremy, Miller, David D., Bamborough, Paul, Christopher, John A., Baldwin, Ian, Osborn, Ruth R., Yonchuk, John, Webb, Edward, Rumsey, William L.
Pubblicato in ACS Med Chem Lett (2018)

Small molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

di Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.
Pubblicazione 2014