Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders

[Image: see text] Structure–activity relationship exploration of the historical biarylurea series led to the identification of novel CNS penetrant CXCR2 antagonists with nanomolar potency, favorable PK profile, and good developability potentials. More importantly, the key compound 22 showed efficacy...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Xu, Heng, Lu, Hongfu, Xu, Zhongmiao, Luan, Linbo, Li, Chengyong, Xu, Yan, Dong, Kelly, Zhang, Jinqiang, Li, Xiong, Li, Yvonne, Liu, Gentao, Gong, Sophie, Zhao, Yong-Gang, Liu, Ailian, Zhang, Yueting, Zhang, Wei, Cai, Xin, Xiang, Jia-Ning, Elliott, John D., Lin, Xichen
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834652/
https://ncbi.nlm.nih.gov/pubmed/27096048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00489
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados