Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders

[Image: see text] Structure–activity relationship exploration of the historical biarylurea series led to the identification of novel CNS penetrant CXCR2 antagonists with nanomolar potency, favorable PK profile, and good developability potentials. More importantly, the key compound 22 showed efficacy...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Xu, Heng, Lu, Hongfu, Xu, Zhongmiao, Luan, Linbo, Li, Chengyong, Xu, Yan, Dong, Kelly, Zhang, Jinqiang, Li, Xiong, Li, Yvonne, Liu, Gentao, Gong, Sophie, Zhao, Yong-Gang, Liu, Ailian, Zhang, Yueting, Zhang, Wei, Cai, Xin, Xiang, Jia-Ning, Elliott, John D., Lin, Xichen
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834652/
https://ncbi.nlm.nih.gov/pubmed/27096048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00489
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