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Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors
[Image: see text] A novel series of biaryl amides was identified as RORγt inhibitors through core replacement of a starting hit 1. Structure–activity relationship exploration on the biaryl moiety led to discovery of potent RORγt inhibitors with good oral bioavailability and CNS penetration. Compound...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2015
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4499822/ https://ncbi.nlm.nih.gov/pubmed/26191367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00122 |
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