Biaryl Amides and Hydrazones as Therapeutics for Prion Disease in Transgenic Mice

The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone termed “Compd B” (4-pyridinecarboxaldehyde,2-[4-(5-oxazolyl)phenyl]hydrazone). However, the hydrazone moiety of Compd B results in toxic metabolites, making it a poor candidate...

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Main Authors: Lu, Duo, Giles, Kurt, Li, Zhe, Rao, Satish, Dolghih, Elena, Gever, Joel R., Geva, Michal, Elepano, Manuel L., Oehler, Abby, Bryant, Clifford, Renslo, Adam R., Jacobson, Matthew P., DeArmond, Stephen J., Silber, B. Michael, Prusiner, Stanley B.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2013
Teme:
Drug Discovery and Translational Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807058/
https://ncbi.nlm.nih.gov/pubmed/23965382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.205799
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