Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains

Because no drug exists that halts or even slows any neurodegenerative disease, developing effective therapeutics for any prion disorder is urgent. We recently reported two compounds (IND24 and IND81) with the 2-aminothiazole (2-AMT) chemical scaffold that almost doubled the incubation times in scrap...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacol Exp Ther
Prif Awduron: Giles, Kurt, Berry, David B., Condello, Carlo, Hawley, Ronald C., Gallardo-Godoy, Alejandra, Bryant, Clifford, Oehler, Abby, Elepano, Manuel, Bhardwaj, Sumita, Patel, Smita, Silber, B. Michael, Guan, Shenheng, DeArmond, Stephen J., Renslo, Adam R., Prusiner, Stanley B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2015
Pynciau:
Drug Discovery and Translational Medicine
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576665/
https://ncbi.nlm.nih.gov/pubmed/26224882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224659
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