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2-Aminothiazoles as Therapeutic Leads for Prion Diseases

2-Aminothiazoles are a new class of small molecules with antiprion activity in prion-infected neuroblastoma cell lines.1 We report here structure-activity studies undertaken to improve the potency and physiochemical properties of 2-aminothiazoles, with a particular emphasis on achieving and sustaini...

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Detalhes bibliográficos
Main Authors: Gallardo-Godoy, Alejandra, Gever, Joel, Fife, Kimberly L., Silber, B. Michael, Prusiner, Stanley B., Renslo, Adam R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041857/
https://ncbi.nlm.nih.gov/pubmed/21247166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101250y
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