Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains

Because no drug exists that halts or even slows any neurodegenerative disease, developing effective therapeutics for any prion disorder is urgent. We recently reported two compounds (IND24 and IND81) with the 2-aminothiazole (2-AMT) chemical scaffold that almost doubled the incubation times in scrap...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Giles, Kurt, Berry, David B., Condello, Carlo, Hawley, Ronald C., Gallardo-Godoy, Alejandra, Bryant, Clifford, Oehler, Abby, Elepano, Manuel, Bhardwaj, Sumita, Patel, Smita, Silber, B. Michael, Guan, Shenheng, DeArmond, Stephen J., Renslo, Adam R., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576665/
https://ncbi.nlm.nih.gov/pubmed/26224882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224659
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