In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists

The orphan nuclear receptor, retinoic acid receptor-related orphan nuclear receptor γt (RORγt), is required for the development and pathogenic function of interleukin-17A-secreting CD4(+) T helper type 17 (Th17) cells. Whereas small molecule RORγt antagonists impair Th17 cell development and attenua...

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Publicado no:Immunology
Main Authors: Skepner, Jill, Trocha, Mark, Ramesh, Radha, Qu, Xiaoyan A, Schmidt, Darby, Baloglu, Erkan, Lobera, Mercedes, Davis, Scott, Nolan, Michael A, Carlson, Thaddeus J, Hill, Jonathan, Ghosh, Shomir, Sundrud, Mark S, Yang, Jianfei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479534/
https://ncbi.nlm.nih.gov/pubmed/25604624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12444
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