Digoxin, an Overlooked Agonist of RORγ/RORγT

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kaja Karaś, Anna Sałkowska, Marta Sobalska-Kwapis, Aurelia Walczak-Drzewiecka, Dominik Strapagiel, Jarosław Dastych, Rafał A. Bachorz, Marcin Ratajewski
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2019-01-01
Sarja:Frontiers in Pharmacology
Aiheet:
RORγ
RORC
Th17
agonist
digoxin
molecular docking
Linkit:https://www.frontiersin.org/article/10.3389/fphar.2018.01460/full
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