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Digoxin, an Overlooked Agonist of RORγ/RORγT

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...

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Autors principals: Kaja Karaś, Anna Sałkowska, Marta Sobalska-Kwapis, Aurelia Walczak-Drzewiecka, Dominik Strapagiel, Jarosław Dastych, Rafał A. Bachorz, Marcin Ratajewski
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019-01-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/article/10.3389/fphar.2018.01460/full
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