Digoxin, an Overlooked Agonist of RORγ/RORγT

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kaja Karaś, Anna Sałkowska, Marta Sobalska-Kwapis, Aurelia Walczak-Drzewiecka, Dominik Strapagiel, Jarosław Dastych, Rafał A. Bachorz, Marcin Ratajewski
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019-01-01
Cyfres:Frontiers in Pharmacology
Pynciau:
RORγ
RORC
Th17
agonist
digoxin
molecular docking
Mynediad Ar-lein:https://www.frontiersin.org/article/10.3389/fphar.2018.01460/full
Tagiau: Ychwanegu Tag
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